Lipid phenotypes in BCG Tokyo 172 types I and II 1 The Lipid Phenotype of two Distinct Subpopulations of Mycobacterium bovis Bacillus Calmette-Guérin Tokyo 172 Substrain*
نویسندگان
چکیده
From the Department of Bacteriology, and Virology, Osaka City University Graduate School of Medicine, Osaka 545-8585, Japan, the MBR Co. Ltd., Osaka 560-8552, Japan, the Molecular Epidemiology Division, Mycobacterium Reference Center, The Research Institute of Tuberculosis, Japan Anti-Tuberculosis Association, Tokyo 204-8533, Japan, the Department of Oral Microbiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, Japan, the Japan BCG Laboratory, Tokyo 204-0022, Japan, and the Departments of Safety Research on Blood and Biological Products, and Immunology, National Institute of Infectious Diseases, Tokyo 2080011, Japan
منابع مشابه
Lipid phenotype of two distinct subpopulations of Mycobacterium bovis Bacillus Calmette-Guerin Tokyo 172 substrain.
Bacillus Calmette-Guérin (BCG) Tokyo 172 is a predominant World Health Organization Reference Reagent for the BCG vaccine. Recently, the BCG Tokyo 172 substrain was reported to consist of two subpopulations with different colony morphologies, smooth and rough. Smooth colonies had a characteristic 22-bp deletion in Rv3405c of the region of difference (RD) 16 (type I), and rough colonies were com...
متن کاملDeep sequencing analysis of the heterogeneity of seed and commercial lots of the bacillus Calmette-Guérin (BCG) tuberculosis vaccine substrain Tokyo-172
BCG, only vaccine available to prevent tuberculosis, was established in the early 20th century by prolonged passaging of a virulent clinical strain of Mycobacterium bovis. BCG Tokyo-172, originally distributed within Japan in 1924, is one of the currently used reference substrains for the vaccine. Recently, this substrain was reported to contain two spontaneously arising, heterogeneous subpopul...
متن کاملLipid phenotypes in BCG Tokyo 172 types I and II 1 The Lipid Phenotype of two Distinct
From the Department of Bacteriology, and Virology, Osaka City University Graduate School of Medicine, Osaka 545-8585, Japan, the MBR Co. Ltd., Osaka 560-8552, Japan, the Molecular Epidemiology Division, Mycobacterium Reference Center, The Research Institute of Tuberculosis, Japan Anti-Tuberculosis Association, Tokyo 204-8533, Japan, the Department of Oral Microbiology, Okayama University Gradua...
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This is the first identified case of Mycobacterium bovis bacillus Calmette-Guerin (BCG)-derived cutaneous tuberculosis that localizes at a place different from the vaccination site in hosts without immune deficiency. A healthy baby with a developing abscess is described. A multiplex PCR identified the abscess as originating from M. bovis BCG Tokyo 172.
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We report a case of chest wall abscess caused by Mycobacterium bovis BCG that arose as a complication 1 year after intravesical BCG instillation. We identified M. bovis BCG Tokyo 172 in the abscess by PCR-based typing of Mycobacterium tuberculosis complex and analysis of variable number of tandem repeats data.
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